凡事預則立，不預則廢。隨著社會對健康越來越重視，預防為主的觀念已深入民心。監測預警系統作為實現預防控制疾病的有效手段，正發揮巨大作用。美國疾病預防控制中心（CDC）的Emerging Infectious Disease(EID) Journal（《新發傳染病》）就在最近一期（Volume 16, Number 5–May 2010）報道了一篇新加坡關于監測預警的文章。

早期預警作為突發公共衛生事件應對體系的基礎，在當中起著至關重要的作用。建立、健全監測預警系統作為我國公共衛生體系建設的重要內容，對推動疾病預防控制體制改革，完善公共衛生體系建設，建立合理有效的疾病流行早期控制機制和突發公共衛生應急機制具有十分重要的意義。

而登革熱是我市重點防治的傳染病，曾經兩次在我市引起暴發或流行，每年4-11月份是登革熱的好發季節，為確保期間2010年廣州亞運會在我市舉辦的賽事順利進行，進一步做好我市登革熱防控工作，及時有效應對登革熱疫情的發生，全面提高我市應對突發公共衛生事件的應急處置能力，保障我市廣大群眾身體健康，我們可以參考借鑒新加坡在這方面的經驗。感興趣的朋友們可以到以下網址查看全文：http://www.cdc.gov/eid/content/16/5/pdfs/847.pdf

Dengue Virus Surveillance for Early Warning, Singapore

新加坡的登革熱病毒監測預警

作者：Kim-Sung Lee, Yee-Ling Lai, Sharon Lo, Timothy Barkham, Pauline Aw, Peng-Lim Ooi, Ji-Choong Tai, Martin Hibberd, Patrik Johansson, Seow-Poh Khoo, and Lee-Ching Ng

作者背景：Environmental Health Institute, Singapore (K.-S. Lee, Y.-L. Lai, S. Lo, L.-C. Ng); Tan Tock Seng Hospital, Singapore (T. Barkham); Genome Institute of Singapore, Singapore (P. Aw, M. Hibberd); Ministry of Health, Singapore (P.-L. Ooi); National Environment Agency, Singapore (J.-C. Tai, S.-P. Khoo); and DSO National Laboratories, Singapore (P. Johansson)

摘要：

In Singapore, after a major outbreak of dengue in 2005, another outbreak occurred in 2007. Laboratory-based surveillance detected a switch from dengue virus serotype 1 (DENV-1) to DENV-2. Phylogenetic analysis showed a clade replacement within DENV-2 cosmopolitan genotype, which accompanied the predominant serotype switch, and cocirculation of multiple genotypes of DENV-3.

Dengue poses a threat to public health in >100 countries worldwide. Despite improvements in diagnostics and clinical management, the number of dengue cases continues to rise globally; 2.5 billion persons are at risk for infection (1). Dengue virus (DENV) belongs to the genus Flavivirus and contains a positive-strand RNA genome that encodes 3 structural proteins—core protein, membrane-associated protein, envelope protein—and 7 nonstructural proteins. DENV consists of 4 genetically and antigenically distinct serotypes, 1–4.

Singapore has seen a resurgence of dengue cases since the late 1980s, after 2 decades of successful control that relied mostly on an integrated vector-control program (2, 3). The recent epidemiology of dengue in Singapore is characterized by a 5–6-year cycle; incidence rates increase within each cycle before collapsing into 1 or 2 lull years. During an unprecedented dengue outbreak in 2005, a total of 14,006 cases and 27 deaths were reported (4). The outbreak was associated with a switch in predominant serotype, from DENV-2 to DENV-1, in 2004 (5,6). In 2007, Singapore experienced another dengue outbreak after a lull in 2006. We report the laboratory and surveillance findings that assisted vector-control operations during the 2007 dengue outbreak in Singapore.

引用建議——請使用以下信息聯系作者：

Lee-Ching Ng, Environmental Health Institute, 11 Biopolis Way, 06-05/08 Helios Block, Singapore 138667; email: ng_lee_ching@nea.gov.sg

（編輯：劉鵬達）